Musculoskeletal Tissue Regeneration

Scientific Federation invites all the participants from all over the world to attend International Summit on Rheumatology& Orthopedics during September 24-25 2018 at Madrid, Spain. This includes Keynote presentations, Oral talks, Poster presentations and Exhibitions.

Musculoskeletal problems continue to represent a growing source of death and disability world-wide, particularly with the growing burden of disease associated with an aging population and increase in the rates of road traffic accidents. To address the societal and economic burdens presented by musculoskeletal disorders, research in the normal biology of musculoskeletal tissues, the diseases and injuries associated with these tissues, and the underlying mechanisms of musculoskeletal tissue regeneration continue to gain importance. It is clear that collaboration between disciplines and centers with expertise in biology, mechanics, and clinical research is essential to continue to advance the field.

The musculoskeletal system involves a diverse organization of tissues exposed to a complex series of biological and mechanical stimuli. A thorough understanding of the normal biology of the musculoskeletal tissues, the behavior of these tissues associated with disease and injury, and the underlying mechanisms of musculoskeletal tissue regeneration is necessary to address the growing burden of disease. Research programs, both in developed and developing countries, must target those orthopedic conditions of greatest importance to their populations in order to diminish the societal and economic burdens caused by an inability to resume necessary physical function. The potential areas for investigation within the field of orthopedics continue to grow, particularly as the basic and applied body of scientific knowledge and technology develop. While these areas for basic research in orthopedics are too numerous to list, below are example of some of the current and future directions in the field.

Bone repair, whether it happens following a fracture or a bone graft, involves a well organized set of events that lead to reconstitution of the biological and mechanical integrity of bone. The regeneration process is initiated by an inflammatory response, which plays an important role in stimulating repair. Simultaneously, skeletal progenitor cells are recruited and begin   differentiating into chondrocytes and osteoblasts  that will deposit new cartilage and bone matrix necessary for bone bridging. The origins of these progenitor cells and the influence of the inflammatory response on their recruitment are not well understood. Following extracellular matrix deposition, cartilage is replaced by bone and new trabecular bone is converted to lamellar bone during the remodeling phase of repair.

The basic biology of muscle and muscle repair is well understood compared to other soft tissues. Muscle repair is composed of three phases including degeneration/ inflammation, regeneration and fibrosis. Many molecular markers and disease models are available. Muscle has been an ideal target to test new gene therapies and cell based therapies, however further advances are needed to treat devastating diseases such as Duchene Muscular Dystrophy and to improve muscle repair.