Skeletal Adaptation: Exercise, Diet, and Osteoarthritis

We are extremely delighted to announce our plenary speakers for the World Congress on Rheumatology &Orthopedics will be:

Ronald Zernicke, PhD, DSc, is a Professor of Orthopaedic Surgery, Kinesiology, and Biomedical Engineering, and a Fellow of the International, Canadian, and American Societies of Biomechanics, American College of Sports Medicine, and National Academy of Kinesiology. He has published more than 600 research papers and abstracts and 2 books. Ronald Zernicke, PhD, DSc, will be giving plenary talk on Skeletal Adaptation: Exercise, Diet, and Osteoarthritis A brief summary is given below:

Throughout the life span, significant skeletal adaptations occur during maturation to maturity, within the mature state, and during senescence with males and females different in this regard. The associated microstructural and mechanical changes can be influenced by intrinsic and extrinsic factors, such as exercise, diet, and joint injury. Although exercise can positively benefit bone, skeletal muscle, and joint health, chronic exposure to an obesity-inducing diet and its inflammatory sequelae can result in loss of functional integrity with dysregulated tissue repair and risk for musculoskeletal tissue damage. Systemic inflammation from diet-induced obesity and metabolic syndrome can adversely affect bone density and subchondral trabecular bone mechanics and structure, which can negatively impact articular cartilage. Joint injuries (e.g., loss of the anterior cruciate ligament—ACL of the knee) can have rapid and detrimental effects on the structure and mechanical integrity of periarticular bone, joint cartilage, and other joint tissues, and thus, a joint should be considered a multicomponent organ system. After an ACL injury, finite element analyses have revealed specific changes in periarticular bone modulus, 3D trabecular connectivity, and microarchitecture, as well as loss of quadriceps muscle complex integrity. With development of early post-traumatic osteoarthritis, architectural adaptations predominate over bone tissue modulus changes. Altered muscle-tendon-bone cross-talk can also be produced from dysfunctional mechanical and biological stimuli resulting from compromised muscle integrity and contribute to bone loss. The potent interconnectivities among musculoskeletal tissues underscore the importance of implementing a complex systems approach to detailed understanding of mechanisms of skeletal adaptation in health and disease.

You can visit the conference webpage: http://scientificfederation.com/rheumatology-orthopedics-2018/